Discovery chemistry

Synthesis of complex molecules: we deliver where others fail.

Aided by latest (chiral) technologies, Syncom is a key partner to pharma and biotech industries for the synthesis of complex molecules. Custom synthesis services include the synthesis of active pharmaceutical ingredients, impurities, metabolites and stable-isotope labelled compounds.

To be specific, we synthesize complex pharmaceutically relevant compound classes like carbohydrates, steroids, vitamin D analogues, nucleotides and macrocycles. In addition, we have extensive experience in the synthesis of stable isotope labelled compounds (2H, 13C and 15N). As part of our discovery services, we synthesize metabolites and impurities on custom basis. In our state-of-the-art laboratories we perform chemical synthesis from milligram to kilogram scale.

Chiral technologies are in the DNA of Syncom. We are world leaders in developing classical resolution processes and invented the Dutch resolution. Syncom is involved in the latest developments in the field of chirality, ranging from enantioselective synthesis to attrition enhanced kinetic resolutions.

In addition to our pharma activities, we serve the diagnostic, fine chemical, electronic and pigment industries.

Do you have a chemistry challenge for us?


Synthesis of complex carbohydrates. Protecting group strategy. Reverse phase chromatography. Spacer-containing oligosaccharides. GalNAc clusters. Stable-labelled carbohydrates.


Synthesis of complex nucleosides and nucleotides. Synthesis of Cangrelor derivatives.

Steroids and vitamin D analogues.

Expertise in multistep synthesis of vitamin D analogues and steroids. Scale up-of building block synthesis. Stable isotope labelling.

Metabolites and impurities

Syncom restocks QC-standards to pharma- and catalogue companies. More than 300 reference compounds, impurities and metabolites currently in stock.

Stable isotope labelled compounds

Synthesis of stable-labelled isotopes (2H, 13C and 15N).

Talk to our specialist

Elena Herrero Gomez

Function: Business Development Director

Email address



+31 50 575 7272